Background and objectives- COVID-19 is a coronavirus disease declared pandemic by WHO. The commonly checked proinflammatory biomarkers are Neutrophil-Lymphocyte ratio (NLR), C - reactive protein (CRP), D-Dimer and Ferritin. High-Resolution Computed Tomography (HRCT) of chest is an important tool to evaluate the diagnosis and prognosis of COVID-19. The objective of this study was to evaluate the relationship between the biomarkers and HRCT findings. Materials and method- This was a multi-center cross-sectional study done in Sylhet Women’s Medical College Hospital (SWMCH), Sylhet Shahid Shamsuddin Ahmed Hospital (SSSAH), Northeast Medical College Hospital (NMCH) and Mount Adora Hospital, Sylhet. Data were collected from electronic medical record (EMR). Relationship test were done by independent t-test and one-way-ANOVA test. Results- Among the total 481 participant, 312 (65%) were male and rest 169 (35%) were female. The average age of the COVID-19 positive group participants was 60.72 year and it was 60.79 year in the COVID-19 negative group. The mean difference of D-Dimer between COVID-19 positive and negative patients was significant (p=0.0063). The mean differences of NLR (p=0.0012) and CRP (p=0.005) were significant between died and survived patients. Conclusion- All four biomarkers were raised in the higher HRCT percentage involved groups. NLR and DDimer were significantly (p<0.001) higher in the higher HRCT percentage groups.