DOI: https://doi.org/10.47648/jswmc2025v15-2-28
Salam MU , Dhar P , Ahmad MM , Saha M , Bristy FA , Ferdous T, Alam S , Rahman S
Abstract
Sheehan’s syndrome (SS) is a form of hypopituitarism, often progressing to panhypopituitarism, which occurs in women due to ischemic necrosis of the pituitary gland following severe postpartum hemorrhage (PPH). This case series describes four patients diagnosed and treated at the Department of Medicine, Sylhet Women’s Medical College (SWMC), Bangladesh. Each patient had a characteristic obstetric history indicating PPH, along with lactational failure following childbirth. Over the years, they developed symptoms attributable to deficiencies of various anterior pituitary hormones. Clinical and biochemical evaluations consistently revealed hypoprolactinemia, hypothyroidism, adrenal insufficiency, and gonadal hormone deficiency. Assessment of growth hormone function was not possible due to limitations in diagnostic resources.Notably, brain MRI revealed an empty sella or partially empty sella in all cases except one.