DOI: NO DOI Assigned
Muhammad Sazzad Hossain, Md. Shahnewaz Choudhury, Md. Waliullah', Ehsan Ali
Hypotension and bradycardia are common drawback of spinal anesthesia during cesarean section. This can have fatal effects on mother and fetus. Ondansetron by blocking Bezold-Jarisch reflex through inhibition of serotonin receptors has been effective in prevention of spinal hypotension and bradycardia. The aim of this study was to determine the effectiveness of intravenous ondansetron in the prevention of hypotension and bradycardia during spinal anesthesia in lower segment cesarean section A total of 100 parturients scheduled for elective cesarean section were scheduled in this study. They were randomly divided into two groups of 50 cach. Both groups were preloaded with Hartmann's Lactate at dose of 10ml/kg. Group A received 04 mg, of ondansetron dilated in 10 mi normal saline slowly intravenously (IV) 05 minutes prior to spinal anesthesia, whereas Group B received 10 ml normal saline slowly intravenously (IV) 05 minades prior to spinal anesthesia. Blood pressure and heart rate were recorded every 3 min. interval. The consumption of vasopressors and atropine were recorded. Average age of Group A was 24.7624 82 years, whereas that of Group B was 25.2145.73 years p>0.05). Average weight of group A was 65.2326.46 kg, whereas that of Group B was 64.83.47 kg (p>0.05). Hypotension was noted in 8 patients in group A (16%), whereas it was observed in 32 patients in group B (64%) (p<0.05) Bradycardia was noted in 5 patients in group A (10%) and 17 patients in group B (34%) (p<0.05). Premedication with intravenous administration of 04 me ondansetron 05 minutes before spinal anesthesia in elective cesarean section significantly reduces hypotension and bradycardia.