DOI: N/A
Nipa NS, Lopa NJ, Zumma AMSU, Tamanna N, Das M, keya JA
Background: Hypothyroidism is a clinical syndrome caused by insufficient production of thyroid hormones, leading to a generalized slowing of metabolic processes. It is a common endocrine disorder, with higher prevalence in women and increasing frequency with age. Subclinical hypothyroidism, characterized by elevated thyroid-stimulating hormone (TSH) with normal T3 and T4 levels, may often remain asymptomatic but can still impact metabolic and organ functions.
Objective: To assess serum creatinine concentrations in patients with hypothyroidism and explore its correlation with thyroid hormone levels.
Materials and Methods: A prospective cross-sectional study was conducted at Northeast Medical College, Sylhet, from July 2024 to June 2025. A total of 110 participants were included, comprising 55 were newly diagnosed hypothyroid patients and 55 were normal thyroid profiles (euthyroid) controls, aged 21–45 years. Statistical analysis was performed using SPSS version 25, with chi-square test, t test and spearman correlation applied to assess significance (p < 0.05).
Results: The mean age of cases was 33.77 ± 6.24 years, and controls 30.91 ± 6.87 years, with a significant age difference (p = 0.026). Females predominated in both groups (cases 89.1%, controls 90.9%), with no significant difference in sex distribution (p = 0.751). Mean serum creatinine was significantly higher in hypothyroid patients (0.926 ± 0.14 mg/dL) compared to controls (0.795 ± 0.087 mg/dL; p = 0.001). Correlation analysis between thyroid hormones and creatinine in hypothyroid patients showed weak and non-significant associations: T3 (r = 0.072, p = 0.455), T4 (r = -0.066, p = 0.500), and TSH (r = 0.154, p = 0.110).
Conclusion: Serum creatinine levels were significantly elevated in individuals with hypothyroidism compared to euthyroid controls, indicating an impact of thyroid dysfunction on renal function. Although correlations between thyroid hormones and serum creatinine were weak and not statistically significant, routine monitoring of renal parameters in hypothyroid patients may be clinically beneficial.