DOI: N/A
Jahan T, Mimi SA, Mahmud S, Neeva NI, Ahmed R
Background: Wound infections causes significant morbidity in addition to escalate of health expenditure and these infections typically begin with bacterial colonization that are highly resistant to drugs.
Objective: The purpose of this study was to evaluate the phenotypic detection and antimicrobial susceptibility pattern of multi-drug resistance organisms (MDROs) isolated from wound infection patients at a tertiary care hospital, Bangladesh.
Methodology: This retrospective study was conducted in the Department of Microbiology at Monno Medical College, Manikganj, Bangladesh during the period from January 2021 to December 2024 for duration of four years. Patients who were presented with wound infection at any site of body and age more than 18 years with both sexes attending at outpatient department were selected as study population. All the samples were inoculated on blood agar and MacConkey agar media and were incubated at for hour at 37°C for 72 hours. Organisms were identified by standard microbiological procedures. Antimicrobial susceptibility test was done for all isolated bacteria by disc diffusion method
Results: Total of 680 patients were recruited for this study, with male patients being predominant at 360 (52.94%). Bacterial growth was observed in 504 cases (74.11%). The predominant isolate was Staphylococcus aureus which was 252 (50.00%) followed by Escherichia coli, Streptococcus pyogenes, Pseudomonas species and Klebsiella species which were 100(19.84%), 72(14.28%), 64(12.69%) and 16(3.17%) respectively. Most resistant antibiotic was cefixime which was 456(90.47%) followed by nitrofurantoin, ceftriaxone and sulphamethoxazole which were 444(88.09%), 432(85.71%) and 424 (84.12%) respectively. The most predominant multidrug resistance bacteria was Pseudomonas species which was 60(93.75%) followed by Klebsiella species, Escherichia coli, Staphylococcus aureus and Streptococcus pyogenes which were 12(75.0%),72(72.00%),180(71.42%) and 48(66.66%) respectively.
Conclusion: In conclusion the predominant isolate is Staphylococcus aureus, moreover the predominant multidrug resistant bacteria was Pseudomonas species followed by Klebsiella species, Escherichia coli, Staphylococcus aureus and Streptococcus pyogenes. Most resistant antibiotic was cefixime. Antibiotic sensitivity pattern will guide for appropriate selection of antibiotics to reduce the spread of resistant bacteria against wound infection.